StatinWISE is a trial designed to find out whether the muscle symptoms experienced during statin use are caused by statins. http://statinwise.lshtm.ac.uk/live/
A randomised trial of expedited transfer to a cardiac arrest centre for non-ST elevation out-of-hospital cardiac arrest. The aim is to determine the best post-resuscitation care pathway for patients without ST-segment elevation (STE). We propose that changes to emergency management comprising...
HALT-IT is a a large, international trial assessing whether early administration of tranexamic acid in people with acute gastrointestinal bleeding can reduce their risk of dying in the hospital. http://haltit.lshtm.ac.uk/
Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention : A multicentre randomised controlled clinical trial. The aim of this trial is to determine whether remote ischaemic...
A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgery. The aim of this trial is to determine if a single dose of intravenous iron administered to...
Revascularisation for Ischaemic Ventricular Dysfunction. The aim of this trial is to evaluate the efficacy and safety of percutaneous coronary intervention compared to optimal medical therapy alone for ischaemic left ventricular dysfunction. http://revived.lshtm.ac.uk/
A randomised controlled trial of an intervention delivered by mobile phone messaging to reduce sexually transmitted infections (STI) by increasing sexual health precaution behaviours in young people. The aim of the trial is to establish the effectiveness of a safer sex intervention delivered by...
CRASH-3 is a large, international, randomised, placebo controlled trial, to quantify the safety and effect on mortality and morbidity of the administration of tranexamic acid in patients with TBI. https://crash3.lshtm.ac.uk/
A prospective, randomised, placebo-controlled double blind, multi-centre study of the effects of Irbesartan on aortic dilatation in Marfan syndrome.