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Current Trial
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WOMAN-2

Postpartum haemorrhage (PPH) is responsible for about 100,000 maternal deaths every year, almost all of which occur in low and middle income countries. When given within three hours of birth, tranexamic acid reduces deaths due to bleeding in women with PPH by almost one third. However, for many...

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Completed Trial
Completed Trial
CRASH-2

The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Among trauma patients who survive to reach hospital, exsanguination is a common cause of...

Current Trial
Current Trial
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StatinWISE

StatinWISE is a trial designed to find out whether the muscle symptoms experienced during statin use are caused by statins. http://statinwise.lshtm.ac.uk/live/

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Current Trial
Current Trial
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ARREST

A randomised trial of expedited transfer to a cardiac arrest centre for non-ST elevation out-of-hospital cardiac arrest. The aim is to determine the best post-resuscitation care pathway for patients without ST-segment elevation (STE). We propose that changes to emergency management comprising...

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Current Trial
HALT-IT

The HALT-IT trial is a a large, international trial assessing whether early administration of tranexamic acid in people with acute gastrointestinal bleeding can reduce their risk of dying in the hospital.  

Completed Trial
Completed Trial
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ERIC-PPCI

Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention : A multicentre randomised controlled clinical trial. The aim of this trial is to determine whether remote ischaemic...

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Completed Trial
Completed Trial
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PREVENTT

A randomised double-blind controlled phase III study to compare the efficacy and safety of intravenous ferric carboxymaltose with placebo in patients with anaemia undergoing major open abdominal surgery. The aim of this trial is to determine if a single dose of intravenous iron administered to...

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Current Trial
Current Trial
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REVIVED BCIS 2

Revascularisation for Ischaemic Ventricular Dysfunction. The aim of this trial is to evaluate the efficacy and safety of percutaneous coronary intervention compared to optimal medical therapy alone for ischaemic left ventricular dysfunction. http://revived.lshtm.ac.uk/

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Completed Trial
Completed Trial
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safetxt

A randomised controlled trial of an intervention delivered by mobile phone messaging to reduce sexually transmitted infections (STI) by increasing sexual health precaution behaviours in young people. The aim of the trial is to establish the effectiveness of a safer sex intervention delivered by...

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Current Trial
CRASH-3

CRASH-3 is a large, international, randomised, placebo controlled trial, to quantify the safety and effect on mortality and morbidity of the administration of tranexamic acid in patients with TBI. Worldwide, over 10 million people are killed or hospitalised because of traumatic brain injury...