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Brenner, Amy 

Research Fellow in Epidemiology


I joined the Clinical Trials Unit as a Research Fellow in 2017. I provide epidemiological expertise for several emergency care trials that aim to investigate the effectiveness of tranexamic acid for the prevention and treatment of life-threatening bleeding. These include the WOMAN-2 trial for the prevention of postpartum haemorrhage, the CRASH-3 trial for the treatment of intracranial haemorrhage, and the HALT-IT trial for the treatment of acute gastrointestinal bleeding. My current research is focussed on the methodological issues and biases that arise when conducting clinical trials in an emergency care setting. I also act as a Practical Facilitator on several MSc modules and as a Personal Tutor. Before joining the School I worked in the Cancer Screening and Prevention Research Group at Imperial College London. I have a BSc in Biological Sciences from Imperial College London, an MSc in Epidemiology from LSHTM, and over 8 years of clinical research experience.



Brenner A, Arribas M, Cuzick J, Jairath V, Stanworth S, Ker K, et al. Outcome measures in clinical trials of treatments for acute severe haemorrhage. Trials. BioMed Central; 2018;19:533. DOI:

Roberts I, Belli A, Brenner A, Chaudhri R, Fawole B, Harris T, Jooma R, Mahmood A, Shokunbi T, Shakur H, +1 more… (2018) Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. Wellcome Open Research, 3. p. 86. ISSN 2398-502X DOI:

Brenner A, Shakur-Still H, Chaudhri, R; Fawole, B; Arulkumaran, S; Roberts, I; WOMAN Trial Collaborators (2018) The impact of early outcome events on the effect of tranexamic acid in post-partum haemorrhage: an exploratory subgroup analysis of the WOMAN trial. BMC Pregnancy and Childbirth, 18 (1). p. 215. ISSN 1471-2393 DOI:

Atkin W, Brenner A, Martin J, Wooldrage K, Shah U, Lucas F, Greliak P, Pack K, Kralj-Hans I, Thomson A, +9 more… (2017) The clinical effectiveness of different surveillance strategies to prevent colorectal cancer in people with intermediate-grade colorectal adenomas: a retrospective cohort analysis, and psychological and economic evaluations. Technical Report. NIHR Health Technology Assessment Programme. DOI:

Atkin W, Wooldrage K, Brenner A, Martin J, Shah U, Perera S, Lucas F, Brown JP, Kralj-Hans I, Greliak P, +6 more… (2017) Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study. The Lancet Oncology, 18 (6). pp. 823-834. ISSN 1470-2045 DOI: